ARTHROSAMID INJECTIONS

Knee osteoarthritis (OA) is a long-term condition where the shock-absorbing cartilage is worn away causing bones to rub together and the joint to become stiff, swollen and painful. The knee joint worsens over time resulting in synovial pain and disability.

Despite OA being the most common type of arthritis and the fastest growing cause of disability worldwide, the treatment area has seen minimal progression in the last 20 years. With so little known about exactly what causes knee OA, a permanent cure has yet to be discovered. As a result, the options available to the one third of over 65s currently living with OA worldwide have been limited, with treatments to date having focused on pain relief and managing the symptoms of the condition.

Synovial pain

Synovial pain is a common symptom experienced by patients with knee OA. This is caused by the inflammation of synovial tissue (the lining) located inside the knee joint, and is strongly linked with the level of pain experienced by knee OA patients.

Of 1,504 respondents surveyed in the UK in March 2024:

43% would pay for non-surgical procedures for chronic joint pain
58% are concerned about side effects of surgery e.g. pain and discomfort
61% are anxious about surgery.

The link between knee OA and synovial pain

Synovial pain is known to play an important role in the development of knee OA. In addition to its relationship with knee pain, there is also strong evidence that synovial pain is associated with further worsening of OA.